Turning the Tide on Cancer by Developing
New Treatment Options in Cancer Indications with the Greatest Medical Need
We are developing onvansertib, an oral and highly-selective inhibitor of Polo-like Kinase 1 (PLK1), in combination with standard-of-care therapeutics, to overcome resistance to current therapies, improve efficacy and increase overall survival in solid tumor and hematologic cancers. Rapidly advancing, ongoing clinical programs continue to demonstrate the safety and clinical benefit of onvansertib.
- Clinical Programs Based on Scientific Rationale: supported by preclinical and synergy data, and integration of biomarkers to rapidly assess response to treatment
- Addressing Significant Medical Need for New Treatment Options:
- Overcome resistance to standard-of-care drugs
- Extend response to treatment and progression-free survival (PFS)
Our Clinical Programs
Zytiga-Resistant Metastatic Castration-Resistant Prostate Cancer (mCRPC)
Adding onvansertib to daily Zytiga® to overcome resistance, extend treatment response and overall survival.
KRAS-Mutated Metastatic Colorectal Cancer (mCRC)
Combining onvansertib with FOLFIRI/Avastin® to improve efficacy by increasing duration of response and overall survival.
Relapsed/Refractory Acute Myeloid Leukemia (AML)
Combining onvansertib with decitabine to provide a new treatment option to improve efficacy and increase overalll survival.