ONSEMBLE mCRC Clinical Programs 1st line mCRC 2nd line mCRC mPDAC The CRDF-004 phase 2 randomized trial for the 1st line treatment of patients with a RAS-mutated metastatic colorectal cancer (mCRC) is designed to generate preliminary safety and efficacy data, and confirm the optimal dose ENDPOINTS Primary Objective Response Rate: CR + PR Key Secondary Duration of ResponseProgression-Free Survival